Data：October 24th 2019 (Thu) 16:30−17:30
Place：Second Lecture Room
Breaking the barrier between commensalism and pathogenicity
Eric Oswald, Professor, PhD and DVM
Digestive Health Research Institute, University of Toulouse
National Veterinary College of Toulouse, Toulouse, France.
The team “Pathogenesis and commensalism of enterobacteriaceae”, led by Pr Eric Oswald, is developing a multidisciplinary approach to study the boundary between commensalism and bacterial pathogenesis. The team is working on several Escherichia coli pathovars such as enteropathogenic and hemorrhagic or extraintestinal pathogens (EPEC and EHEC or ExPEC), but also commensal and probiotic E. coli. In 2006, the team identified a genomic island, the pks island, which codes for a complex enzymatic machinery synthesizing several secondary metabolites, including colibactin, a genotoxin produced by certain strains of E. coli. This secondary metabolite of the polyketide/non-ribosomal peptide type induces double-stranded DNA breaks. The objective of the seminar will be to present the team’s latest work on colibactin biosynthesis and its role in virulence, carcinogenesis and more paradoxically in the activity of certain probiotics.
Organized by Shinji Yamasaki,
Professor of Laboratory of Prevention of International Epidemics
Department of Veterinary Science
Graduate School of Life and Environmental Sciences