業績

(2020)

Numakura Y, Uemura R, Tanaka M, Izawa T, Yamate J, Kuramoto T, Kaneko T, Mashimo T, Yamamoto T, Serikawa T, Kuwamura M
PHF24 is expressed in the inhibitory interneurons in rats.
Exp Anim (in press)

Inai Y, Izawa T, Mori M, Atarashi M, Tsuchiya S, Kuwamura M, Yamate J
Analyses of hemorrhagic diathesis in rats fed a high-iron diet.
J Toxicol Pathol (in press)

Yamazaki H, Sasai H, Tanaka M, Tanaka T, Nishida H, Noguchi S, Kuwamura M, Akiyoshi H
Assessment of biomarkers influencing treatment success on small intestinal lymphoma in dogs.
Vet Comp Oncol (in press) doi: 10.1111/vco.12653.

Fujimoto Y, Kuwamura M, Azuma YT
Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure.
J Vet Med Sci (in press) doi: 10.1292/jvms.20-0344.

Rahman N, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Characterization of immature myofibroblasts of stellate cell or mesenchymal cell origin in D-galactosamine-induced liver injury in rats.
Vet Pathol (in press)

Harada N, Minami Y, Hanada K, Hanaoka R, Kobayashi Y, Izawa T, Sato T, Kato S, Inui H, Yamaji R
Relationship between gut environment, feces-to-food ratio, and androgen deficiency- induced metabolic disorders.
Gut Microbes (in press) doi: 10.1080/19490976.2020.1817719.

Kanegae H, Tomino N, Nakamura Y, Minakawa T, Yaguchi T, Izawa T, Sano A, Ueda K
Parengyodontium album isolated from cutaneous lesions of a pacific white-sided dolphin (Lagenorhynchus obliquidens) during treatment for Paracoccidioidomycosis Ceti.
Mycopathologica (in press) doi: 10.1007/s11046-020-00484-3.

Hada N, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Effects of dexamethasone on hepatic macrophages in normal livers and thioacetamide-induced acute liver lesions in rats.
J Toxicol Pathol (in press)

Mori M, Izawa T, Inai Y, Aikawa R, Fujiwara S, Kuwamura M, Yamate J
Dietary iron overload differentially modulates chemically-induced liver injury in rats.
Nutrients 12(9):2784, 2020. doi: 10.3390/nu10101400.

Tsukamoto M, Kimura K, Tanaka M, Kuwamura M, Ohtaka M, Nakanishi M, Sugiura K, Hatoya S
Generation of footprint-free canine induced pluripotent stem cells from peripheral blood mononuclear cells using sendai virus vector.
Mol Reprod Dev. 87(6):663-665, 2020. doi: 10.1002/mrd.23349.

Hashikawa Y, Hayashi R, Tajima M, Okubo T, Azuma S, Kuwamura M, Takai N, Osada Y, Kunihiro Y, Mashimo T, Nishida K.
Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas9.
Sci Rep 10(1):9957, 2020. doi: 10.1038/s41598-020-66780-6.

Katou-Ichikawa C, Nishina H, Tanaka M, Takenaka S, Izawa T, Kuwamura M, Yamate J
Participation of somatic stem cells, labeled by a unique antibody (A3) recognizing both n-glycan and peptide, to hair follicle cycle and cutaneous wound healing in rats.
Int J Mol Sci 21(11): 3806, 2020. doi: 10.3390/ijms21113806.

Takami Y, Izawa T, Tanaka M, Hatoya S, Nabetani T, Yamate J, Kuwamura M
Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog.
J Vet Med Sci 82(6):704-706, 2020. doi: 10.1292/jvms.20-0045.

Nishina H, Kato-Ichikawa C, Kuramochi, M, Izawa T, Kuwamura M, Yamate J
Participation of somatic stem cells, recognized by a unique A3 antibody, in mucosal epithelial regeneration in dextran sulfate sodium (DSS)-induced rat colonic lesions.
Toxicol Pathol 48(4):560-569, 2020. doi: 10.1177/0192623320906817.

Morita C, Tanaka M, Noguchi S, Shimamura S, Wada Y, Izawa T, Yamate J, Kuwamura M
An aortic body carcinoma with sarcomatoid morphology and chondroid metaplasia in a French Bulldog.
J Vet Med Sci 82(5):576-579, 2020. doi: 10.1292/jvms.20-0016. 

Hashimoto A, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Characterization of macrophages and myofibroblasts appearing in dibutyltin dichloride-induced rat pancreatic fibrosis.
Toxicol Pathol 48(3):509-523, 2020. doi: 10.1177/0192623319893310.

Kuramochi M, Izawa T, Mori M, Shimamura S, Shimada T, Kuwamura M, Yamate J
Diffuse leiomyomatosis with circumferential thickening of the gastrointestinal wall, resembling human diffuse leiomyomatosis, in a young miniature dachshund.
J Vet Med Sci 82(2):139-142, 2020. doi: 10.1292/jvms.19-0453.

Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C
Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting.
Int J Pharm 576:119021, 2020. doi: 10.1016/j.ijpharm.2020.119021.

Wijesekera DP, Yuba E, De Silva NH, Watanabe S-I, Tsukamoto M, Ichida C, Izawa T, Itoh K, Kanegi R, Hatoya S, Yamate J, Inaba T, Sugiura K
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB BioAdvance 2(1): 5–17, 2020. doi: 10.1096/fba.2019-00052.

Konishi S, Tanaka N, Mashimo T, Yamamoto T, Sakuma T, Kaneko T, Tanaka M, Izawa T, Yamate J, Kuwamura M
Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
Exp Anim 69(1):26–33, 2020. doi: 10.1538/expanim.19-0005. 

Nishitani A, Yoshihara T, Tanaka M, Kuwamura M, Asano M, Tsubota Y, Kuramoto T
Muscle weakness and impaired motor coordination in Hcn1- deficient rats.
Exp Anim 69(1):11-17, 2020. doi: 10.1538/expanim.19-0067

(2019)

Tsuji Y, Kuramochi M, Izawa T, Akiyoshi H, Yamate J, Kuwamura M
Hepatic myoepithelial carcinoma in a dog: immunohistochemical comparison with other canine hepatic carcinomas.
Vet Pathol 56(6):889-894, 2019. doi: 10.1177/0300985819854439.

Sabry R, Yamate J, Favetta L, LaMarre J
MicroRNAs: potential targets and agents of endocrine disruption in female reproduction.
J Toxicol Pathol 32(4):213-221, 2019. doi: 10.1293/tox.2019-0054.

Kuwamura M, Tanimura S, Hasegawa Y, Hoshiai R, Moriyama Y, Tanaka M, Takenaka S, Nagayoshi H, Izawa T, Yamate J, Kuramoto T, Serikawa T
Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect.
Brain Res 1718:169-175, 2019. doi: 10.1016/j.brainres.2019.05.017. 

Atarashi M, Izawa T, Kuwamura M, Yamate J
The role of iron overload in the progression of nonalcoholic steatohepatitis (NASH).
Folia Pharmacol Jpn 154:61-65, 2019. doi: 10.1254/fpj.154.61.

Ioannidis M, Tanaka M, Yasui S, Kezuka C, Oyamada M, Hasegawa T, Izawa T, Yamate J, Kuwamura M
Late onset of cerebellar cortical degeneration in a Magellanic penguin (Spheniscus magellanicus).
J Vet Med Sci 81(5):750–752, 2019. doi: 10.1292/jvms.19-0089.

Rahman N, Kezuka C, Higashiguchi N, Kosaka N, Izawa T, Yamate J, Kuwamura M
Spontaneous peripheral neuritis in two electric eels (Electrophorus electricus).
J Vet Med Sci 81(5):744–746, 2019. doi: 10.1292/jvms.18-0751.

Horikawa A, Yoneda T, Yaoita E, Yamaguchi K, Shigenobu S, Kuramochi M, Yamate J, Inui T, Ishibashi O
A novel splicing variant of small nucleolar RNA host gene 4 is a podocyte-selective non-coding RNA upregulated in response to puromycin aminonucleoside-induced podocyte injury.
J Biochem 165(5):447-454, 2019. doi: 10.1093/jb/mvy118.

Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT
Chronic kidney disease following 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility.
J Cell Physiol 234(5):6667-6678, 2019. doi: 10.1002/jcp.27408. 

Mori M, Izawa T, Sasaki H, Sonoyama J, Nishimura S, Shimamura S, Shimada T, Hasegawa T, Kuwamura M, Yamate J
A case of feline t-cell lymphoma with tropism for striated muscle and peripheral nerve.
J Comp Pathol 168:8-12, 2019. doi: 10.1016/j.jcpa.2019.02.002.

Koga M, Kuramochi M, Karim MR, Izawa T, Kuwamura M, Yamate J
Immunohistochemical characterization of myofibroblasts appearing in isoproterenol-induced rat myocardial fibrosis.
J Vet Med Sci 81(1):127-133, 2019. doi: 10.1292/jvms.18-0599. 

Nishina H, Katou-Ichikawa C, Kuramochi M, Izawa T, Kuwamura M, Yamate J
The localization and distribution of cells labeled by a somatic stem cell-recognizing antibody (A3) in rat colon development; possible presence of a new cell type forming intestinal stem cell niche.
J Toxicol Pathol 32(1):37-48, 2019. doi: 10.1293/tox.2018-0037. 

(2018)

Terada N, Karim MR, Izawa T, Kuwamura M, Yamate J
Expression of β-catenin in regenerating renal tubules of the cisplatin-induced kidney failure in rats.
Clin Exp Nephrol 22(6):1240-1250, 2018. doi: 10.1007/s10157-018-1583-1.

Caswell JL, Bassel LL, Rothenburger JL, Gröne A, Sargeant JM, Beck AP, Ekman S, Gibson-Corley KN, Kuiken T, LaDouceur EEB, Meyerholz DK, Origgi FC, Posthaus H, Priestnall SL, Ressel L, Sharkey L, Teixeira LBC, Uchida K, Ward JM, Webster JD, Yamate J
Observational Study Design in Veterinary Pathology, Part 2: Methodology.
Vet Pathol 55(6):774-785, 2018.  doi: 10.1177/0300985818798121.

Tsukamoto M, Nishimura T, Yodoe K, Kanegi R, Tsujimoto Y, Alam ME, Kuramochi M, Kuwamura M, Ohtaka M, Nishimura K, Nakanishi M, Inaba T, Sugiura K, Hatoya S
Generation of footprint-free canine induced pluripotent stem cells using auto-erasable sendai virus vector.
Stem Cells Dev 27(22):1577-1586, 2018. doi: 10.1089/scd.2018.0084. 

Yamaguchi T, Kato Y, Okuda T, Rokushima M, Izawa T, Kuwamura M, Yamate J
Visualization of specific collagen-producing cells by Col1-GFP transgenic mice revealed novel type I collagen-producing cells other than fibroblasts in systemic organs/tissues.
Biochem Biophys Res Commun 505(1):267-273, 2018. doi: 10.1016/j.bbrc.2018.09.082.

Atarashi M, Izawa T, Mori M, Inai Y, Kuwamura M, Yamate J
Dietary iron overload abrogates chemically-induced liver cirrhosis in rats.
Nutrients 10(10):1400, 2018. doi: 10.3390/nu10101400.

Mitori H, Izawa T, Kuwamura M, Matsumoto M, Yamate J
Gene expression profile in retinal excitotoxicity induced by L-glutamate in neonatal rats.
J Toxicol Pathol 31(4):301-306, 2018. doi: 10.1293/tox.2018-0026.

Rahman N, Pervin M, Kuramochi M, Karim MR, Izawa T, Kuwamura M, Yamate J
M1-/M2-macrophage polarization-based hepatotoxicity in D-galactosamine-induced acute liver injury in rats
Toxicol Pathol 46(7):764-776, 2018. doi: 10.1177/0192623318801574.

Tanaka M, Kuramochi M, Nakanishi S, Kuwamura M. Kuramoto T
Rat polymorphous 2 infection in a colony of X-linked severe combined immunodeficiency rats in Japan.
J Vet Med Sci 80(9):1400-1406, 2018. doi: 10.1292/jvms.18-0107.

Caswell JL, Bassel LL, Rothenburger JL, Gröne A, Sargeant JM, Beck AP, Ekman S, Gibson-Corley KN, Kuiken T, LaDouceur EEB, Meyerholz DK, Origgi FC, Posthaus H, Priestnall SL, Ressel L, Sharkey L, Teixeira LBC, Uchida K, Ward JM, Webster JD, Yamate J.
Observational Study Design in Veterinary Pathology, Part 1: Study Design.
Vet Pathol 55(5):607-621, 2018. doi: 10.1177/0300985818785705. 

Kato Y, Masago Y, Kondo C, Yogo E, Torii M, Hishikawa A, Izawa T, Kuwamura M, Yamate J
Comparison of acute gene expression profiles of islet cells obtained via laser capture microdissection between alloxan- and streptozotocin-treated rats.
Toxicol Pathol 46(6):660-670, 2018. doi: 10.1177/0192623318783957.

Watanabe-Takahashi M, Yamasaki S, Murata M, Kano F, Motoyama J, Yamate J, Omi J, Sato W, Ukai H, Shimasaki K, Ikegawa M, Tamura-Nakano M, Yanoshita R, Nishino Y, Miyazawa A, Natori Y, Toyama-Sorimachi N, Nishikawa K
Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.
Sci Rep 8(1):10776, 2018. doi: 10.1038/s41598-018-29128-9.

Nakamura R, Makino T, Hanada T, Terakawa M, Nagahira K, Yamate J, Shiraishi H, Motomura M
Heterogeneity of auto-antibodies against nAChR in myasthenic serum and their pathogenic roles in experimental autoimmune myasthenia gravis.
J Neuroimmunol 320:64-75, 2018. doi: 10.1016/j.jneuroim.2018.04.014.

Matsuyama S, Karim MR, Izawa T, Kuwamura M, Yamate J
Immunohistochemical analyses of the kinetics and distribution of macrophages in the developing rat kidney.
J Toxicol Pathol 31(3):207-212, 2018. doi: 10.1293/tox.2018-0002.

Pervin M, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Macrophage populations and expression of regulatory inflammatory factors in hepatic macrophage-depleted rat livers under lipopolysaccharide (LPS) treatment.
Toxicol Pathol 46(5):540-552, 2018. doi: 10.1177/0192623318776898.

Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT
The role of interleukin-19 in contact hypersensitivity.
Biol Pharma Bull 41(2):182-189, 2018. doi: 10.1248/bpb.b17-00594.

Atarashi M, Izawa T, Miyagi R, Ohji S, Hashimoto A, Kuwamura M, Yamate J
Dietary iron supplementation alters hepatic inflammation in a rat model of nonalcoholic steatohepatitis.
Nutrients 10(2):175, 2018. doi: 10.3390/nu10020175.

(2017)

Bondoc A, GolbarHM, Pervin M, Katou-Ichikawa C, Tanaka M, Izawa T, Kuwamura M, Yamate J
Participation of tumor-associated myeloid cells in progression of amelanotic melanoma (RMM tumor line) in F344 rats, with particular reference to MHC class II- and CD163-expressing cells.
Cancer Microenviron 10(1-3):9-24, 2017. doi: 10.1007/s12307-017-0193-x. 

De Silva NH, Akazawa T, Wijewardana V, Inoue N, Oyamada M, Ohta A, Tachibana Y, Wijesekera DPH, Kuwamura M, Nishizawa Y, Itoh K, Izawa T, Hatoya S, Hasegawa T, Yamate J, Inaba T, Sugiura K
Development of effective tumor immunotherapy using a novel dendritic cell–targeting Toll-like receptor ligand.
PLoS One 12(11):e0188738, 2017. doi: 10.1371/journal.pone.0188738. 

Tanaka M, Yamaguchi S, Akiyoshi H, Tsuboi M, Uchida K, Izawa T, Yamate J, Kuwamura M
Ultrastructural features of canine neuroaxonal dystrophy in a Papillon dog.
J Vet Med Sci 79(12):1927-1930, 2017. doi: 10.1292/jvms.17-0487. 

Hashimoto A, Karim MR, Izawa T, Kuwamura M, Yamate J
Immunophenotypical analysis of pancreatic interstitial cells in developing rat pancreas and myofibroblasts in fibrotic pancreas in dogs and cats.
J Vet Med Sci 79(12):1920-1926, 2017. doi: 10.1292/jvms.17-0423. 

Terada N, Karim MR, Izawa T, Kuwamura M, Yamate J
Immunolocalization of beta-catenin, E-cadherin and N-cadherin in neonate and adult rat kidney.
J Vet Med Sci 79(11):1785-1790, 2017. doi: 10.1292/jvms.17-0439. 

Kuramoto T, Yokoe M, Kunisawa N, Ohashi K, Miyake T, Higuchi Y, Yoshimi K, Mashimo T, Tanaka M, Kuwamura M, Kaneko S, Shimizu S, Serikawa T, Ohno Y
Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel.
Brain Res 1676:38-45, 2017. doi: 10.1016/j.brainres.2017.09.012.

Kuramoto T, Voigt B, Nakanishi S, Kitada K, Nakamura T, Wakamatsu K, Uemura R, Tanaka M, Kuwamura M, Shimizu S, Ohno Y, Sasa M, Serikawa T
Identification of candidate genes for generalized tonic–clonic 1 seizures in Noda Epileptic Rat.
Behav Genet 47(6):609-619, 2017. doi: 10.1007/s10519-017-9870-2.

Nishina H, Izawa T, Ozaki M, Kuwamura M, Yamate J
Unilateral luteoma of the ovary in a pregnant Risso’s dolphin (Grampus griseus).
J Vet Med Sci 79(10):1749-1752, 2017. doi: 10.1292/jvms.17-0172.

Makino T, Nakamura R, Terakawa M, Muneoka S, Nagahira K, Nagane Y, Yamate J, Motomura M, Utsugisawa K
Analysis of peripheral B cells and autoantibodies against the anti-nicotinic acetylcholine receptor derived from patients with myasthenia gravis using single-cell manipulation tools.
PLoS One 12(10):e0185976, 2017. doi: 10.1371/journal.pone.0185976.

Kuramochi M, Izawa T, Pervin M, Bondoc A, Kuwamura M, LaMarre J, Yamate J
Attenuation of thioacetamide-induced hepatocellular injury by short-term repeated injections associated with down-regulation of metabolic enzymes and relationship with MHC class II-presenting cells.
Exp Toxicol Pathol 69(8):589-597, 2017. doi: 10.1016/j.etp.2017.05.005.

Kato Y, Masuno K, Fujisawa K, Tsuchiya N, Torii M, Hishikawa A, Izawa T, Kuwamura M, Yamate J
Characterization of pancreatic islet cell tumors and renal tumors induced by a combined treatment of streptozotocin and nicotinamide in male SD rats.
Exp Toxicol Pathol 69(7):413-423, 2017. doi: 10.1016/j.etp.2017.03.007. 

Tsuji M, Uemoto K, Kawasaki T, Ishizuka Y, Izawa T
A case report of complete remission in feline gastric small B-cell lymphoma after helicobacter eradication therapy.
J Jpn Vet Med Assoc 70:523-528, 2017

Tanaka N, Izawa T, Yamate J, Kuwamura M
Spontaneous nephroblastoma with striated muscle differentiation in a F344 rat.
J Toxicol Pathol 30(3):231-234, 2017. doi: 10.1293/tox.2017-0004.

Kuramochi M, Izawa T, Nishimura S, Shimada T, Kuwamura M, Yamate J
Pleomorphic adenoma of the labial gland, characterized by reticular pattern of myoepithelial cells in a dog.
J Vet Med Sci 79(7):1163-1166, 2017. doi: 10.1292/jvms.17-0117.

Golbar HM, Izawa T, Bondoc A, Wijesundera KK, Tennakoon AH, Kuwamura M, Yamate J
Attenuation of alpha-naphthylisothiocyanate (ANIT)-induced biliary fibrosis by depletion of hepatic macrophages in rats.
Exp Toxicol Pathol 69(4):221-230, 2017. doi: 10.1016/j.etp.2017.01.005. 

Kasamoto S, Masumori S, Tanaka J, Ueda M, Fukumuro M, Nagai M, Yamate J, Hayashi M
Reference control data obtained from an in vivo comet-micronucleus combination assay using Sprague Dawley rats.
Exp Toxicol Pathol 69(4):187-191, 2017. doi: 10.1016/j.etp.2017.01.002.

Tanaka N, Izawa T, Takenaka S, Akiyoshi H, Yamate J, Kuwamura M
Expression of Ccdc85C, a causative protein for murine hydrocephalus, in the mammary gland tumors of dogs.
Histol Histopathol 32(4):397-403, 2017. doi: 10.14670/HH-11-806.

Karim MR, Izawa T, Pervin M, Sasai H, Kuwamura M, Yamate J
Cutaneous histiocytic sarcoma with regional lymph node metastasis in a Netherland Dwarf rabbit (Oryctolagus cuniculus).
J Comp Pathol 156(2-3):169-172, 2017. doi: 10.1016/j.jcpa.2016.10.009.

Nakajima H, Itakura M, Kubo T, Kaneshige A, Harada N, Izawa T, Azuma YT, Kuwamura M, Yamaji R, Takeuchi T
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death.
J Biol Chem 292(11):4727-42, 2017. doi: 10.1074/jbc.M116.759084.

Fujimoto Y, Azuma YT, Matsuo Y, Kuwamura M, Kuramoto N, Miki M, Azuma N, Teramoto M, Nishiyama K, Izawa T, Nakajima H, Takeuchi T
Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis.
Naunyn Schmiedebergs Arch Pharmacol 390(3):261-268, 2017. doi: 10.1007/s00210-016-1329-0.

Tsuboi M, Watanabe M, Nibe K, Yoshimi N, Kato A, Sakaguchi M, Yamato O, Tanaka M, Kuwamura M, Kushida K, Ishikura T, Harada T, Chambers J, Sugano S, Uchida K, Nakayama H
Whole exome sequencing analysis identifies c.1579G>A missense mutation of PLA2G6 gene as a cause of neuroaxonal dystrophy in papillon dogs.
PLoS One 12(1): e0169002, 2017. doi: 10.1371/journal.pone.0169002.

(2016)

Kokoshima H, Yamada N, Doi T, Tsuchitani M, Yamate J
Histopathological and immunohistochemical characterization of spontaneous pituitary tumors in dwarfs derived from Wistar Hannover GALAS rats.
Exp Toxicol Pathol 68(2-3):191-6, 2016. doi: 10.1016/j.etp.2015.11.001. 

Mitori H, Izawa T, Kuwamura M, Matsumoto M, Yamate J
Developing Stage-dependent Retinal Toxicity Induced by l-glutamate in Neonatal Rats.
Toxicol Pathol. 44(8):1137-1145, 2016. doi: 10.1177/0192623316676424.

Shimotsuma Y, Tanaka M, Izawa T, Yamate J, Kuwamura M
Enhanced expression of Trib3 during the development of myelin breakdown in dmy myelin mutant rats.
PLoS One 11(12): e0168250, 2016. doi: 10.1371/journal.pone.0168250.

Harada N, Hanaoka R, Hanada K, Izawa T, Inui H, Yamaji R
Hypogonadism alters cecal and fecal microbiota in male mice.
Gut Microbes 7(6):533-539, 2016. doi: 10.1080/19490976.2016.1239680.

Ogata K, Kushida M, Miyata K, Sumida K, Takeda S, Izawa T, Kuwamura M, Yamate J
Alteration of microRNA expressions in the pons and medulla in rats after 3,3′-iminodipropionitrile administration.
J Toxicol Pathol. 29(4):229-236, 2016. doi: 10.1293/tox.2016-0019. 

Yamate J, Izawa T, Kuwamura M
Histopathological analysis of rat hepatotoxicity based on macrophage functions: in particular, an analysis for thioacetamide-induced hepatic lesions.
Food Safety 3:61-73, 2016. doi: 10.14252/foodsafetyfscj.2016012.

Kuramochi M, Izawa T, Pervin M, Bondoc A, Kuwamura M, Yamate J
The kinetics of damage-associated molecular patterns (DAMPs) and Toll-like receptors during thioacetamide-induced acute liver injury in rats.
Exp Toxicol Pathol 68(8):471-7, 2016. doi: 10.1016/j.etp.2016.06.005. 

Bondoc A, Katou-Ichikawa C, Golbar HM, Tanaka M, Izawa T, Kuwamura M, Yamate J
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expresison in vivo and in vitro.
Histol Histopathol 31(11):1195-207, 2016

Pervin M, Izawa T, Ito S, Kuwamura M, Yamate J
Metastatic Liposarcoma in a South African Fur Seal (Arctocephalus pusillus).
J Com Pathol 155(1):72-5, 2016. doi: 10.1016/j.jcpa.2016.05.008.

Nishitani A, Tanaka M, Shimizu S, Yokoe M, Yoshida Y, Suzuki T, Sakuma T, Yamamoto T, Kuwamura M, Takenaka S, Ohno Y, Kuramoto T
Involvement of aspartoacylase in tremor expression in rats.
Exp Anim 65(3):293-301, 2016. doi: 10.1538/expanim.16-0007. 

Minakawa T, Ueda K, Tanaka M, Tanaka N, Kuwamura M, Izawa T, Konno N, Yamate J, Nakagawa Itano E, Sano A, Wada S
Detection of multiple budding yeast cells and a partial sequence of 43-kda glycoprotein coding gene of Paracoccidioides brasiliensis from a case of lacaziosis in a female pacific white-sided dolphin (Lagenorhynchus obliquidens).
Mycopathologica 181(7-8):523-9, 2016. doi: 10.1007/s11046-016-9988-4.

Wijesundera KK, Izawa T, Tennakoon AH, Golbar HM, Tanaka M, Kuwamura M, Yamate J
M1-/M2-macrophage polarization in pseudolobules consisting of adipophilin-rich hepatocytes in thioacetamide (TAA)-induced rat hepatic cirrhosis.
Exp Mol Pathol 101:133-42, 2016. doi: 10.1016/j.yexmp.2016.07.005.

Katou-Ichikawa C, Izawa T, Sasai H, Kuwamura M, Yamate J
Multiple histiocytic foam cell nodules in the tongue of miniature dachshund dogs.
Vet Pathol 53(3):625-8, 2016. doi: 10.1177/0300985815594850. 

Pervin M, Golbar HM, Bondoc A, Izawa T, Kuwamura M, Yamate J
Transient effects of empty liposomes on hepatic macrophage populations in rats.
J Toxicol Pathol 29(2):139–144, 2016. doi: 10.1293/tox.2015-0082.

Pervin M, Golbar HM, Bondoc A, Izawa T, Kuwamura M, Yamate J
Immunophenotypical characterization and influence on liver homeostasis of depleting and repopulating hepatic macrophages in rats injected with clodronate.
Exp Toxicol Pathol 68(2-3):113-24, 2016. doi: 10.1016/j.etp.2015.11.003. 

Golbar HM, Izawa T, Wijesundera KK, Bondoc A, Tennakoon A, Kuwamura M, Yamate J
Depletion of hepatic macrophages aggravates liver lesion induced in rats by thioacetamide (TAA).
Toxicol Pathol 44(2):246-58, 2016

Bessho T, Okada T, Kimura C, Shinohara T, Tomiyama A, Imamura A, Kuwamura M, Nishimura K, Fujimori K, Shuto S, Ishibashi O, Kubata BK, Inui T
Novel characteristics of Trypanosoma brucei guanosine 5′-monophosphate reductase distinct from host animals.
PLoS Negl Trop Dis 10(1):e0004339, 2016. doi: 10.1371/journal.pntd.0004339.

Ayata M, Tanaka M, Kameoka K, Kuwamura M, Takeuchi K, Takeda M, Kanou K, Ogura H
Amino acid substitutions in the heptad repeat A and C regions of the F protein responsible for neurovirulence of measles virus Osaka-1 strain from a patient with subacute sclerosing panencephalitis.
Virology 487:141-9, 2016. doi: 10.1016/j.virol.2015.10.004.

Tennakoon AH, Izawa T, Kuwamura M, Yamate J
Pathogenesis of the type 2 of epithelial to mesenchymal transition (EMT) in renal and hepatic fibrosis.
J Clin Med 5(1):4, 2016. doi: 10.3390/jcm5010004.

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