業績

2021年

  1. Minamihata T, Takano K, Nakamura Y, Seto R, Moriyama M. Increase in cellular lysophosphatidylserine content exacerbates inflammatory responses in LPS-activated microglia. Neurochem. Res. In press (2021)
  2. Kuwahara Y, Yoshizaki K, Nishida H, Kamishina H, Maeda S, Takano K, Fujita N, Nishimura R, Jo J-I, Tabata Y, Akiyoshi H. Extracellular vesicles derived from canine mesenchymal stromal cells in serum free culture medium have anti-inflammatory effect on microglial cells. Frontiers in Veterinary Science. 8 633426. DOI: 10.3389/fvets.2021.633426
  3. Moriyama M, Nishimura Y, Kurebayashi R, Minamihata T, Kawabe K, Takano K, Nakamura Y. Acetate suppresses lipopolysaccharide-stimulated nitric oxide production in primary rat microglia but not in BV-2 microglia cells. Curr. Mol. Pharmacol. 14: 253-260. DOI: 10.2174/1874467213666200420101048

2020年

  1. Saheki T, Moriyama M, Funahashi A, Kuroda E. AGC2 (Citrin) deficiency-From recognition of the disease till construction of therapeutic procedures. Biomolecules. 10 (8) 1100. DOI: 10.3390/biom10081100
  2. Minamihata T, Moriyama M, Takano K, Nakamura Y. Lysophosphatidylinositol, an endogenous ligand for G protein-coupled receptor 55, has anti-inflammatory effects in cultured microglia. Inflammation 43: 1971-1987. DOI: 10.1007/s10753-020-01271-4.

2019年

  1. Saheki T, Moriyama M, Kuroda E, Funahashi A, Yasuda I, Setogawa Y, Gao Q, Ushikai M, Furuie S, Yamamura KI, Takano K, Nakamura Y, Eto K, Kadowaki T, Sinasac DS, Furukawa T, Horiuchi M, Tai YH. Pivotal role of inter-organ aspartate metabolism for the treatment of citrin deficiency, based on the mouse model. Scientific Reports 9:4179. DOI: 10.1038/s41598-019-39627-y

2018年

  1. Takano K, Koarashi K, Kawabe K, Itakura M, Nakajima H, Moriyama M, Nakamura Y. Insulin expression in cultured astrocytes and the decrease by amyloid β. Neurochemistry International 119: 171-177. DOI: 10.1016/j.neuint.2017.10.017.
  2. Takano K, Ishida N, Kawabe K, Moriyama M, Hibino S, Choshi T, Hori O, Nakamura Y. A dibenzoylmethane derivative inhibits lipopolysaccharide-induced NO production in mouse microglial cell line BV-2. Neurochemistry International 119: 126-131. DOI: 10.1016/j.neuint.2017.04.002.
  3. Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Nakamura Y. Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPR40-dependent pathway. Neurochemical Research 43: 1723-1735. DOI: 10.1007/s11064-018-2587-7.
  4. Moriyama M, Hashimoto, A, Satoh H, Kawabe K, Takano K, Nakamura Y. S-Equol, a major isoflavone from soybean, inhibits nitric oxide production in lipopolysaccharide-stimulated rat astrocytes partially via the GPR30-mediated pathway. International Journal of Inflammation 8496973. DOI: 10.1155/2018/8496973.
  5. Moriyama M, Fujitsuka, S, Kawabe K, Takano K, Nakamura Y. Zinc potentiates lipopolysaccharide-induced nitric oxide production in cultured primary rat astrocytes. Neurochemical Research 43: 363-374. DOI: 10.1007/s11064-017-2431-5.
  6. Takano K, Ogawa M, Kawabe K, Moriyama M, Nakamura Y. Inhibition of gap junction elevates glutamate uptake in cultured astrocytes. Neurochemical Research 43: 50-56. DOI: 10.1007/s11064-017-2316-7.
  7. Kawabe K, Takano K, Moriyama M, Nakamura Y. Microglia endocytose amyloid β through the binding of transglutaminase 2 and milk fat globule EGF factor 8 protein. Neurochemical Research 43: 32-40. DOI: 10.1007/s11064-017-2284-y.

2017年

  1. Kawabe K, Takano K, Moriyama M, Nakamura Y. Transglutaminases derived from astrocytes accelerate amyloid β aggregation. Neurochemical Research 42: 2384-2391. doi: 10.1007/s11064-017-2258-0.
  2. Kawabe K, Takano K, Moriyama M, Nakamura Y. Amphotericin B increases transglutaminase 2 expression associated with upregulation of endocytotic activity in mouse microglial cell line BV-2. Neurochemical Research 42: 1488-1495. doi: 10.1007/s11064-017-2205-0
  3. Saheki T, Inoue K, Ono Y, Fujimoto Y, Furuie S, Yamamura K-I, Kuroda E, Ushikai M, Asakawa A, Inui A, Horiuchi M, Eto K, Kadowaki T, Moriyama M, Sinasac DS, Yamamoto T, Furukawa T, Kobayashi K. Oral aversion to dietary sugar, ethanol and glycerol correlates with alterations in specific hepatic metabolites in a mouse model of human citrin deficiency. Molecular Genetics and Metabolism 120: 306-316. doi: 10.1016/j.ymgme.2017.02.004.
  4. Takano K, Komada Y, Kawabe K, Moriyama M, Nakamura Y. Exendin-4 increases extracellular superoxide dismutase expression in cultured astrocytes. Global Drugs and Therapeutics 2 (5) 1-6. DOI: 10.15761/GDT.1000S1001
  5. Kawabe K, Takano K. Microglial endocytosis and transglutaminases. Drugs and Therapeutics 2 (4) 1-3. DOI: 10.15761/GDT.1000132.
  6. 佐伯武頼、森山光章　シトリン欠損症の分子病態と生化学的診断マーカー　神経内科 87: 102-109.

2016年

  1. Takano K, Komada Y, Kawabe K, Moriyama M, Nakamura Y: Exendin-4 increases extracellular superoxide dismutase expression in cultured astrocytes. DOI:10.15761/GDT.1000S1001
  2. Moriyama M, Kurebayashi R, Kawabe K, Takano K, Nakamura Y.: Acetate Attenuates Lipopolysaccharide-Induced Nitric Oxide Production Through an Anti-Oxidative Mechanism in Cultured Primary Rat Astrocytes. Neurochemical Research 41:3138-3146., DOI:10.1007/s11064-016-2038-2

2015年

  1. Mitsuaki Moriyama, Yuki Fujimoto, Shizuka Rikimaru, Miharu Ushikai, Eishi Kuroda, Kenji Kawabe, Katsura Takano, Akihiro Asakawa, Akio Inui, Kazuhiro Eto, Takashi Kadowaki, David S Sinasac, Yoshiyuki Okano, Masahide Yazaki, Shu-Ichi Ikeda, Chunhua Zhang, Yuan-Zong Song, Osamu Sakamoto, Shigeo Kure, Hiroshi Mitsubuchi, Fumio Endo, Masahisa Horiuchi, Yoichi Nakamura, Ken-Ichi Yamamura, Takeyori Saheki: Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency. Biochimica et Biophysica Acta 1852: 1787-1795, DOI:10.1016/j.bbadis.2015.04.023
  2. Kenji Kawabe, Katsura Takano, Mitsuaki Moriyama, Yoichi Nakamura: Lipopolysaccharide-Stimulated Transglutaminase 2 Expression Enhances Endocytosis Activity in the Mouse Microglial Cell Line BV-2. NeuroImmunoModulation 22: 243-249, DOI:10.1159/000365484

2014年

  1. Akiko Motoyoshi-Yamashiro, Katsura Takano, Kenji Kawabe, Takeshi Izawa, Hidemitsu Nakajima, Mitsuaki Moriyama, Yoichi Nakamura: Amphotericin B Induces Glial Cell Line-Derived Neurotrophic Factor in the Rat Brain. Journal of Veterinary Medical Science 76: 1353-1358, DOI:10.1292/jvms.14-0160
  2. Mizue Ogawa, Katsura Takano, Kenji Kawabe, Mitsuaki Moriyama, Hideshi Ihara, Yoichi Nakamura: Theophylline Potentiates Lipopolysaccharide-Induced NO Production in Cultured Astrocytes. Neurochemical Research 39: 107-116, DOI:10.1007/s11064-013-1195-9

2013年

  1. Katsura Takano, Nobuyuki Tanaka, Kenji Kawabe, Mitsuaki Moriyama, Yoichi Nakamura: Extracellular Superoxide Dismutase Induced by Dopamine in Cultured Astrocytes. Neurochemical Research 38: 32-41, DOI:10.1007/s11064-012-0882-2
  2. Akiko Motoyoshi-Yamashiro, Mizuho Tamura, Mitsuaki Moriyama, Katsura Takano, Kenji Kawabe, Hidemitsu Nakajima, Ritsuko Katoh-Semba, Teiichi Furuichi, Yoichi Nakamura: Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors production. Neurochemistry International 62: 93-100, DOI:10.1016/j.neuint.2013.05.007

2012年

  1. Katsura Takano, Hiroshi Yamasaki, Kenji Kawabe, Mitsuaki Moriyama, Yoichi Nakamura: Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes. Journal of Pharmacological Sciences 120: 176-186, DOI:10.1254/jphs.12039FP
  2. Ichiro Iitsuka, Akiko Motoyoshi-Yamashiro, Mitsuaki Moriyama, Yukiko Kannan-Hayashi, Yuka Fujimoto, Katsura Takano, Koji Murakami, Yukio Yoneda, Yoichi Nakamura: Extracellular Superoxide Dismutase in Cultured Astrocytes: Decrease in Cell-Surface Activity and Increase in Medium Activity by Lipopolysaccharide-Stimulation. Neurochemical Research 37:2108-2116, DOI:10.1007/s11064-012-0832-z